posted 10-31-1999 07:40 PM         

Isosafrole > MDP2P Via Modified Performic Acid

Combine 16.25 grams of Isosafrole with 50 ml DCE (Dichloroethane) or [DCM] plus 5 Grams Sodium bicarbonate (Sodium Hydrogen Carbonate), let it stirr for 3 hours.

Slowly combine 25 grams 86% Formic acid and 15.1 grams 38% Hydrogen Peroxide (to create Performic acid) and cool to 0 C.

*Then drip the Performic acid VERY VERY slowly , into the ISO-DCE-SBC mix, keeping temp under 40 C until in, and stir vigerously for 10 hours.

Stop stirring and let it sit for one hour in seperatory funnel.It will be orange juice color on top and clearish peracid mix on bottom, seperate into new FBF (orange layer) .Evaporate (no vacuum) off the DCE and stock it for future use.

Add 180 grams of 15% Sulfuric acid (H2SO4), boil it to reflux with slight addition of Methanol (60ml) and condenser added for 2 hrs.

Let it cool and extract with DCM, boil off solvent for brown oil that is peppery and cardamon smell.
Around 16 grams MDP2P.

Thanks Inadvance